- ANTI-INFLAMMATORY AGENTS
- ANTI-INFECTIVE AGENTS
- OPHTHALMOLOGICAL DRUGS
- Pharmaceutical Form : Eye Ointments
- Composition : Fluorometholone 1 mg+ Gentamicine Sulphate 3 mg / 1g
- Active Substance : Fluorometholone+Gentamicine Sulphate
Gentamicin: Gentamicin belongs to the group of bacterial amino-glycoside antibiotic .
the Present situation of susceptibility still covers a broad spectrum of gram – positive and gram – negative Pathogens, including Pseudomonas aeruginosa ,Staphylococci , Haemophiles influenza and egypticus Klebsiella Enterobacteria , proteus ,Escherichia coli , Shigella and Salmonella .
Fluorometholone: Fluorometholone is a synthetic corticosteroid possessing anti-inflammatory properties it exerts a striking effect on lymphoid tissues , and to a lesser degree than other steroids immunological reactions.
the combination brings concomitantly the bacterial treatment or prophylaxis and anti-inflammatory effects . In addition the presence of Gentamicin protects from a risk of potential aggravation of a bacterial Infection due to the steroids .
-Infection of the anterior segment of the eye due to bacteria susceptible to Gentamicin, include Conjunctivitis , keratitis and keratoconjunctivitis , blepharitis and blepharoconjunctivitis ,Acute meibomainitis ,and dacryocystitis .
Contra Indications -Hypersensitivity against Gentamicin , Fluorometholone , benzalkonium chloride or Any of the components
– corneal ulcers.
-Viral infections ( e.g. herpes simplex , vaccinia ) or fungal infections .
– Eye tuberculosis .
– Glaucoma .
Adverse reactions :a transient burning at instillation has been reported in a few cases .
rare : hypersensitivity reactions with itching , redding and photosensitivity .
– Prolonged use of steroids may cause raised intra ocular pressure , although with Fluorometholone The incidence is much less than with other steroids .
– steroids may delay wound healing after intra ocular surgery .
if applied immediately after surgery.
-Long term treatment with steroids may enhance thinning of cornea and sclera, and rarely , perforation Of the cornea has been reported .
Pregnancy and lactation :
-No controlled studies in humans are available .Administration during pregnancy and lactation is Therefore not recommended , except for compelling reasons .
Dosage/and Administration :
Eye drops : bacterial infections :
The dosage depends on the severity of the affection .
The application of 1 drop 5 times daily Instilled into the conjunctival sac of the affected eye is recommended .
Eye ointment :
bacterial infections :
apply 3-4 times daily into the affected eye .
Bottle 10 ml Eye drops.
Tube 5 g. Eye ointment